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But in some cases, the condition isn't apparent until later in life. Normally, these nerve cells signal to the muscles of the bowel to alternatively contract and relax, to move stool along through the colon to the rectum. The most obvious sign that a newborn has Hirschsprung's disease is that the baby does not have a bowel movement within the first 48 hours after birth, the Mayo Clinic sa ys. In older children, the symptoms can include a swollen belly, constipation, gas and fatigue, according to the Mayo Clinic. A number of other conditions can cause a large build-up of poop in the colon in adults, including problems with the movements of the colon, blockages and twists in the intestine called volvulus. Other symptoms can include a swollen belly, vomiting a green or brown substance, constipation, gas or diarrhea.

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In those with Hirschsprung's disease, the nerves do not reach the end of the bowel.

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The most obvious sign that a newborn has Hirschsprung's disease is that the baby does not have a bowel movement within the first 48 hours after birth, the Mayo Clinic sa ys. The disease is difficult to diagnose in adults, according to the case report. Without nerve cells, the bowel cannot effectively move stool through it, which can lead to severe constipation , according to the NIDDKD. These cells first form at the top of the bowel and grow toward the opposite end.

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